DLS: A Link Prediction Method Based on Network Local Structure for Predicting Drug-Protein Interactions

A knowledge-based hybrid method for protein secondary structure prediction based on local prediction confidence

Motivation: In our previous approach, we proposed a hybrid method for protein secondary structure prediction, called HYPROSP, which combined our proposed knowledge-based prediction algorithm PROSP and PSIPRED. The knowledge base constructed for PROSP contains small peptides together with their secondary structural information. The hybrid strategy of HYPROSP uses a global quantitative measure, m...

Link Prediction using Network Embedding based on Global Similarity

Background: The link prediction issue is one of the most widely used problems in complex network analysis. Link prediction requires knowing the background of previous link connections and combining them with available information. The link prediction local approaches with node structure objectives are fast in case of speed but are not accurate enough. On the other hand, the global link predicti...

Predicting Drug-Drug Interactions Through Large-Scale Similarity-Based Link Prediction

Drug-Drug Interactions (DDIs) are a major cause of preventable adverse drug reactions (ADRs), causing a significant burden on the patients’ health and the healthcare system. It is widely known that clinical studies cannot sufficiently and accurately identify DDIs for new drugs before they are made available on the market. In addition, existing public and proprietary sources of DDI information a...

Predicting Drug-Drug Interactions Through Similarity-Based Link Prediction Over Web Data

Drug-Drug Interactions (DDIs) are a major cause of preventable adverse drug reactions and a huge burden on public health and the healthcare system. On the other hand, there is a large amount of drug-related (open) data published on the Web, describing various properties of drugs and their relationships to other drugs, genes, diseases, and related concepts and entities. In this demonstration, we...

PrePPI: A NOVEL STRUCTURE-BASED METHOD FOR PREDICTING PROTEIN-PROTEIN INTERACTIONS